Centanafadine for ADHD

Centanafadine is a

• Noradrenaline reuptake inhibitors
• Dopamine reuptake inhibitors
• Serotonin reuptake inhibitors (weak)

Two randomized, double-blind, placebo-controlled, parallel-group phase 3 studies were conducted in adults with ADHD using 200 mg/d or 400 mg/d centanafadine sustained-release tablets.¹²
At Day 42, both studies showed improvements in AISRS total score compared to placebo with Effect sizes of -0.28 for 200 mg/d and -0.24 for 400 mg/d in Study 1 and -0.37 for 200 mg/d and -0.40 for 400 mg/d in Study 2.

Centanafadine was well tolerated and the overall rate of adverse events was low, but dose-dependent.
A 52-week study found fewer side effects with centanafadine than with lisdexamfetamine, methylphenidate and atomoxetine, with a worse Effect size than lisdexamfetamine and comparable Effect size to methylphenidate³ and thus showed the best adjusted overall benefit (Effect size in relation to side effects).⁴

Centanafadine is currently being studied in several clinical trials for its efficacy and safety in children and adolescents with ADHD (NCT05279313, NCT05428033, NCT05257265).⁵