Frustration intolerance in ADHD - neurophysiological correlates

Irritable adolescents show lower thresholds for anger when they do not receive an expected reward.¹² Irritable adolescents show reduced selective attention and response inhibition compared to normally developed peers.³

Several neurophysiological correlates have been reported for frustration intolerance (reduced frustration thresholds, e.g. when an expected reward is not received):⁴

Amygdala less activated²⁵⁶
Striatum less activated²⁵
anterior and posterior cingulum less activated²⁵
middle frontal gyrus less activated²⁵
anterior cingulum increased activated⁶
middle frontal gyrus increased activation⁶
lateral PFC increased activated
- for children aged 3 to 5 years⁷
greater N2 amplitude in the EEG and reduced no-go accuracy
- for children aged 4-7 years⁸

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Frustration intolerance in ADHD - neurophysiological correlates