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2. Minerals for ADHD

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2. Minerals for ADHD

2.1. Zinc

2.1.1. Zinc deficiency affects dopamine transporters and melatonin

Zinc can increase dopamine levels by reducing the activity of the .

  • of zinc deficiency:
    • Population-wide
      • Europe: 11 % (0.8 to 28.8 %)
      • In Germany, 9.8 % (women) and 10.3 % (men) of adults (aged 19 to 64) and 13.4 % (women) and 8 % (men) of older people (aged 65 and over) stated that their intake was too low.
    • Healthy children from 1 to 3 years:
      • Western Europe: 31.3 %
    • in children under five years of age (Disease Control Priorities in Developing Countries 2006).
      • East Asia/Pacific: 7 %
      • Eastern Europe and Central Asia: 10%
      • Latin America and the Caribbean: 33 %
      • Middle East and North Africa: 46 %
      • Sub-Saharan Africa: 50 %
      • South Asia: 79 %
    • Zinc deficiency manifests itself in a lack of T and B lymphocytes, among other things
    • Zinc deficiency often goes hand in hand with vitamin A deficiency

medication, nicotine and zinc block the dopamine transporters () (too frequently present in the brain in ) and thus reduce their overactivity.. Zinc therefore acts as a dopamine reuptake inhibitor.

Zinc deficiency can influence the modulation of melatonin. Melatonin regulates dopamine function. Melatonin deficiency can cause sleep disorders.

Dysregulation of zinc or copper can increase susceptibility to oxidative damage to tissues or oxidative stress to the brain by damaging antioxidant defenses, which may be a possible cause.

2.1.2. Zinc deficiency and

Zinc can possibly supplement and improve methylphenidate therapy. However, the dosage of zinc used in the aforementioned study requires medical supervision to avoid iron or copper deficiency as well as gastrointestinal complaints or zinc flu. However, the reported improvements were impressive.
Whether the effect exists independently of therapy is unknown. Differentiating Krause.

It is possible that the metabolism of cobalt, copper, lead, zinc and vanadium is altered in . Reduced cycle stability (determinism), duration (mean diagonal length) and complexity (entropy) of the exposure profiles were found.

One study found 19% less zinc in the hair of children with . Low zinc hair levels could also be used as a predictor for
In contrast, a comprehensive meta-analysis of 11 studies involving 1,311 subjects was unable to find any relevant differences in zinc levels in the blood or hair of people with compared to those without. The results of the individual studies are very heterogeneous.

One study found average blood serum levels in children with compared to those not affected:

  • Zinc: 7 % lower
  • Chromium: 21 % reduced
  • Magnesium: 4 % reduced
  • Copper-zinc ratio: 11 % increased

Zinc supplementation for people with with zinc deficiency without iron deficiency

  • Improved statistically significantly
    • Hyperactivity
    • Attention
    • Impulsiveness
    • Mood stability
  • Remained unchanged
    • Intelligence
    • Cognitive problems
    • Oppositional problems

Zinc and iron supplementation for people with with zinc deficiency and iron deficiency

  • Improved statistically significantly
    • Verbal IQ
    • Total IQ
    • Hyperactivity
    • Impulsiveness
    • Mood stability
  • Remained unchanged
    • Performance IQ
    • Attention
    • Cognitive problems
    • Oppositional problems

One study found elevated levels of zinc in the blood and hair of children with hyperactivity and ODD or CD, whereby the study apparently equated hyperactivity with . The study also found a frequent deficiency of magnesium. In the children with magnesium deficiency, the administration of magnesium also improved symptoms.

One large study found reduced zinc levels in the blood of children with , while levels of magnesium, copper, iron and lead were unchanged. Several other studies and a meta-analysis also reported lower zinc levels in and an association between zinc levels and the severity of symptoms.
A Chinese meta-analysis of k = 17 studies with n = 5,077 children found reduced serum zinc levels in children with (SMD: 1.33).
A meta-analysis reports that zinc deficiency is primarily associated with . A randomized double-blind study also found that zinc supplementation in addition to existing treatment with (only) further improved inattention, but not hyperactivity, impulsivity or the overall score.
A meta-analysis found a positive effect of zinc on .

As a result, it can be concluded that zinc levels are not generally altered in . However, the results of zinc supplementation in individual people with indicate that an existing zinc deficiency can contribute to the intensification of symptoms in some persons with . Therefore, the zinc level and the functionality of the zinc receptors should be checked individually during diagnostics. If deficits are found here, zinc supplementation should be able to reduce symptoms in these people with .

Even in the case of an existing deficiency, the administration of zinc or other vitamins or minerals should not be expected to achieve anywhere near the Effect size of medication. However, correcting any deficiencies in vitamins or minerals can be helpful for .

2.2. Magnesium

Seven studies consistently found reduced magnesium blood levels in people with .

In 15q11.2 BP1-BP2 microdeletion syndrome (Burnside-Butler syndrome), the following symptoms were found among 200 people with :

  • Developmental disorders (73 %)
  • Speech disorders (67 %)
  • Memory difficulties (60 %)
  • Writing problems (60 %)
  • Reading problems (57%)
  • Verbal IQ below 76 (50 %)
  • Behavioral problems (55 %)
  • Dysmorphic ears (46 %)
  • Anomalies on the front palate (46 %)
  • Motor slowdown (42 %)
  • Abnormalities in brain imaging (43%)
  • (35 %)
  • Autism spectrum disorders (27%)
  • Epilepsy (26 %)
  • Schizophrenia / paranoid psychoses (20 %)

It is assumed that magnesium administration can be helpful here.

In children with , magnesium was found to be 29% lower in the hair. However, low hair magnesium levels could not be used as a diagnostic tool for .

One study found average blood serum levels in children with compared to those not affected:

  • Zinc: 7 % lower
  • Chromium: 21 % reduced
  • Magnesium: 4 % reduced
  • Copper-zinc ratio: 11 % increased

In children with aged 6 to 12 years, a double-blind placebo-controlled study found that 50,000 IU D3 per week and 6 mg/kg/day of magnesium significantly improved symptoms in the areas of conduct disorder, social behavior and anxiety, but not psychosomatic symptoms.

One study found a frequent lack of magnesium in the blood and hair of children with hyperactivity. In the children with magnesium deficiency, magnesium administration also improved symptoms, although the study apparently equated hyperactivity with .

2.3. Iron, ferritin

The prevalence of insufficient iron intake in Europe is between 0% and 20%. In Germany, 7.1% of adults (aged 19 to 64) were reported to have an insufficient intake of iron (men), and 6.1% (women) and 4.5% (men) for older people (aged 65 and over).

A meta-analysis found a between ferritin levels as a marker of iron levels in and the risk of in children. Another meta-analysis found a positive effect of iron in . A third meta-analysis also found a association between iron deficiency and . A further meta-analysis does not appear to have found a clear between iron and
Another meta-analysis concluded that serum ferritin levels were lower in (10 studies, n = 3,387), while there was no between serum iron levels and (6 studies, n = 986).
Another meta-analysis found lower serum ferritin levels in children with and a of iron deficiency to as well as to more severe symptoms.

A large study of 432 children found significantly lower serum levels of iron in children with . This correlated with an increased intake of nutrient-poor foods such as foods high in sugar and fat and a lower intake of vegetables, fruit and protein-rich foods than in healthy children.
It remains to be seen whether the change in diet is the cause, consequence or vicious circle of .

In contrast, three other studies found no between iron deficiency and .

Another study found significantly reduced levels of iron in the brains of people with in

  • Globus pallidus
  • Thalamus
  • Nucleus ruber

This iron deficiency in the brain in is eliminated by stimulant medication. The increase in iron in the brain correlated with the duration of stimulant administration and was greater in older children than in younger children. Iron deficiency may therefore be a consequence and not a cause of , which is consistent with the very manageable Effect size of treatment of iron deficiency in on symptoms

One study found lower iron levels in the limbic region of the striatum in children with . Lower tissue iron levels in the limbic striatum correlated with higher severity of symptoms, while lower tissue iron levels in the left limbic striatum only correlated with severity of anxious, depressive and affective symptoms.

Iron can cross the blood-brain barrier by means of the transferrin receptor.

One study found that severe iron deficiency could reduce oxytocin, dopamine, irisin, MAO-A, β-endorphin and α-MSH in the brain and increase synaptophysin.

One review found clear evidence of a between iron deficiency and restless legs sleep problems, as well as possible evidence of s with sleep problems in .

Iron-deficient rodents develop the major neurochemical changes common in restless legs (RLS), such as decreased striatal D2 receptors. They also develop hyperarousal

Around 10% of Europeans suffer from an iron deficiency. Particularly frequently affected are

  • Women
    in particular:
    • of childbearing age
    • after menstruation
    • during pregnancy
    • during breastfeeding
  • Children
  • Teenagers
  • Dialysis patients
  • for inflammation
    • intestinal diseases
    • Gastritis
  • Heart failure
  • Cancer diseases

Symptoms of iron deficiency can be

  • Brittle, dull, fragile hair
  • Hair loss
  • Rough, cracked skin
  • Cracked corners of the mouth
  • Brittle nails
  • Hollow nails (nails that bend inwards)
  • Burning tongue with pain when swallowing
  • Abnormal cravings, for example for lime, soil or ice cubes (picacism)
  • Impaired (athletic) performance
  • Depression
  • Headache
  • Tiredness
  • Concentration problems
  • Restless legs (restless legs)
  • Sleep disorders

Excess iron is just as harmful as iron deficiency. As with all vitamins and minerals:

  1. measure first (repeat annually)
  2. then just fill the deficit

During infections, iron supplementation can be detrimental.

2.4. Niacin

Source: Bieger. Bieger operates a laboratory and sells food supplements. Its own products were recommended in laboratory analyses without the conflict of interest being disclosed.

2.5. Manganese

Manganese can affect the system.

A meta-analysis found increased manganese levels in the hair but not in the blood of children with . Another study found 27% less manganese in the hair of children with . However, low hair manganese levels could not be used as a diagnostic tool for .

Manganese exposure is occasionally discussed as a possible cause of . One study found that this depends on the genotype of the manganese transporter and that girls are more sensitive to reactions to manganese than boys. A meta-analysis also reported a link between manganese exposure and hyperactive behavior.

Another study reported that the administration of methylphenidate significantly reduced manganese levels.

2.6. Copper

It is possible that the metabolism of cobalt, copper, lead, zinc and vanadium is altered in . Reduced cycle stability (determinism), duration (mean diagonal length) and complexity (entropy) of the exposure profiles were found.

The prevalence of insufficient iron intake in Europe is between 8% and 24%.

Dysregulation of copper or zinc can increase susceptibility to oxidative damage to tissues or oxidative stress to the brain by damaging antioxidant defenses, which may be a possible cause.

Several enzymes thought to play an essential role in the neurophysiology of are copper-dependent.

Excess copper can promote the oxidation of dopamine and its metabolite salsolinol, which leads to the degeneration of neurons.

Children with were found to have 10% less copper in their hair. However, low hair copper levels could not be used as a diagnostic tool for .

One study found average blood serum levels of in children with compared to those not affected:

  • Zinc: 7 % lower
  • Chromium: 21 % reduced
  • Magnesium: 4 % reduced
  • Copper-zinc ratio: 11 % increased
    • Copper therefore increases

Another study on children with diabetes 1 and also found an increased copper-to-zinc ratio.

One study found reduced levels in plasma, erythrocytes, urine and hair in children with increased hyperactivity of

  • Magnesium
  • Zinc
  • Copper
  • Iron
  • Calcium

A large study found decreased levels of zinc in the blood of children with , while levels of magnesium, copper, iron and lead were unchanged.

One study found no change in copper blood levels in children with . Changes in copper blood levels or ceruloplasmin blood levels also did not correlate with symptoms within the group of subjects.
One study found slight evidence of a role for copper in . No evidence of a connection was found for other micronutrients.

2.7. Cobalt

Children with were found to have 18% less cobalt in their hair. However, low hair cobalt levels could not be used as a diagnostic tool for .

2.8. Silicon

Children with were found to have 16% less silicon in their hair. However, low hair silicon levels could not be used as a diagnostic tool for .

2.9. Chrome

One study found altered blood serum levels in children with compared to those not affected:

  • Zinc: 7 % lower
  • Chromium: 21 % reduced
  • Magnesium: 4 % reduced
  • Copper-zinc ratio: 11 % increased

Another study found altered levels in the hair of children with of

  • Bismuth: 8-fold increased
  • Chromium: 15 % reduced (and strongest predictor of symptoms)
  • Germanium: 11 % reduced

2.10. Vanadium

It is possible that the metabolism of cobalt, copper, lead, zinc and vanadium is altered in . Reduced cycle stability (determinism), duration (mean diagonal length) and complexity (entropy) of the exposure profiles were found.

2.11. Bismuth

One study found altered levels in the hair of children with of

  • Bismuth: 8-fold increased
  • Chromium: 15 % reduced (and strongest predictor of symptoms)
  • Germanium: 11 % reduced

2.12. Germanium

One study found altered levels in the hair of children with of

  • Bismuth: 8-fold increased
  • Chromium: 15 % reduced (and strongest predictor of symptoms)
  • Germanium: 11 % reduced

2.13. Magnesium L-threonate

A very small study claims to have found benefits from the administration of magnesium L-threonate. Magnesium L-threonate is a compound of magnesium and L-threonic acid. Magnesium L-threonate is a degradation product of vitamin C.


  1. Lepping, Huber (2010): Role of zinc in the pathogenesis of attention-deficit hyperactivity disorder: implications for research and treatment. CNS Drugs. 2010 Sep;24(9):721-8. doi: 10.2165/11537610-000000000-00000.

  2. Scassellati, Bonvicini, Faraone, Gennarelli (2012): Biomarkers and Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analyses. Journal of the American Academy of Child & Adolescent Psychiatry, Volume 51, Issue 10, 1003 – 1019.e20

  3. Roman Viñas, Ribas Barba, Ngo, Gurinovic, Novakovic, Cavelaars, de Groot, van’t Veer, Matthys, Serra Majem (2011): Projected prevalence of inadequate nutrient intakes in Europe. Ann Nutr Metab. 2011;59(2-4):84-95. doi: 10.1159/000332762. PMID: 22142665.

  4. Vreugdenhil, Akkermans, van der Merwe, van Elburg, van Goudoever, Brus (2021): Prevalence of Zinc Deficiency in Healthy 1-3-Year-Old Children from Three Western European Countries. Nutrients. 2021 Oct 22;13(11):3713. doi: 10.3390/nu13113713. PMID: 34835970; PMCID: PMC8621620. n = 278

  5. Steinhausen, Rothenberger, Döpfner (2010): Handbuch ADHS, Seite 78

  6. Sandyk (1990): Zinc Deficiency in Attention-Deficit Hyperactivity Disorder, International Journal of Neuroscience, 52:3-4, 239-241, DOI: 10.3109/00207459009000526

  7. Coogan, McGowan (2017): A systematic review of circadian function, chronotype and chronotherapy in attention deficit hyperactivity disorder. ADHD Attention Deficit and Hyperactivity Disorders. September 2017, Volume 9, Issue 3, pp 129–147

  8. Scassellati, Bonvicini, Faraone, Gennarelli (2012): Biomarkers and Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analyses. Journal of the American Academy of Child & Adolescent Psychiatry, Volume 51, Issue 10, 1003 – 1019.e20

  9. Akhondzadeh, Mohammadi, Khademi (2004): Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: a double blind and randomized trial [ISRCTN64132371]. BMC Psychiatry. 2004 Apr 8;4:9., n = 44

  10. Krause, Krause (2014): ADHS im Erwachsenenalter: Symptome – Differenzialdiagnose – Therapie, Schattauer, Seite 287

  11. Austin, Curtin, Curtin, Gennings, Arora, Tammimies, Isaksson, Willfors, Bölte (2019): Dynamical properties of elemental metabolism distinguish attention deficit hyperactivity disorder from autism spectrum disorder. Transl Psychiatry. 2019 Sep 25;9(1):238. doi: 10.1038/s41398-019-0567-6.

  12. Tinkov, Mazaletskaya, Ajsuvakova, Bjørklund, Huang, Chernova, Skalny, Skalny (2019): ICP-MS Assessment of Hair Essential Trace Elements and Minerals in Russian Preschool and Primary School Children with Attention-Deficit/Hyperactivity Disorder (ADHD). Biol Trace Elem Res. 2019 Nov 5. doi: 10.1007/s12011-019-01947-5.

  13. Luo, Mo, Liu (2019): Blood and hair zinc levels in children with attention deficit hyperactivity disorder: A meta-analysis. Asian J Psychiatr. 2019 Sep 26;47:101805. doi: 10.1016/j.ajp.2019.09.023.

  14. Skalny, Mazaletskaya, Ajsuvakova, Bjørklund, Skalnaya, Chao, Chernova, Shakieva, Kopylov, Skalny, Tinkov (2019): Serum zinc, copper, zinc-to-copper ratio, and other essential elements and minerals in children with attention deficit/hyperactivity disorder (ADHD). J Trace Elem Med Biol. 2019 Dec 6;58:126445. doi: 10.1016/j.jtemb.2019.126445. n = 136

  15. El-Baz, Youssef, Khairy, Ramadan, Youssef (2019): Association between circulating zinc/ferritin levels and parent Conner’s scores in children with attention deficit hyperactivity disorder. Eur Psychiatry. 2019 Sep 20;62:68-73. doi: 10.1016/j.eurpsy.2019.09.002.

  16. Starobrat-Hermelin (1998): Wpływ niedoboru wybranych biopierwiastków na nadpobudliwość psychoruchowa u dzieci z określonymi zaburzeniami psychicznymi [The effect of deficiency of selected bioelements on hyperactivity in children with certain specified mental disorders]. Ann Acad Med Stetin. 1998;44:297-314. Polish. PMID: 9857546. n = 116

  17. Yang, Zhang, Gao, Lin, Li, Zhao (2019): Blood Levels of Trace Elements in Children with Attention-Deficit Hyperactivity Disorder: Results from a Case-Control Study. Biol Trace Elem Res. 2019 Feb;187(2):376-382. doi: 10.1007/s12011-018-1408-9. PMID: 29909491. n = 814

  18. Bekaroğlu, Aslan, Gedik, Değer, Mocan, Erduran, Karahan (1996): Relationships between serum free fatty acids and zinc, and attention deficit hyperactivity disorder: a research note. J Child Psychol Psychiatry. 1996 Feb;37(2):225-7. doi: 10.1111/j.1469-7610.1996.tb01395.x. PMID: 8682903. n = 93

  19. Tabatadze, Kherkheulidze, Kandelaki, Kavlashvili, Ivanashvili (2018): ATTENTION DEFICIT HYPERACTIVITY DISORDER AND HAIR HEAVY METAL AND ESSENTIAL TRACE ELEMENT CONCENTRATIONS. IS THERE A LINK? Georgian Med News. 2018 Nov;(284):88-92. PMID: 30618396. n = 70

  20. Scassellati, Bonvicini, Faraone, Gennarelli (2012): Biomarkers and attention-deficit/hyperactivity disorder: a systematic review and meta-analyses. J Am Acad Child Adolesc Psychiatry. 2012 Oct;51(10):1003-1019.e20. doi: 10.1016/j.jaac.2012.08.015. PMID: 23021477. METASTUDIE

  21. Sun GX, Wang BH, Zhang YF (2015): [Relationship between serum zinc levels and attention deficit hyperactivity disorder in children]. Zhongguo Dang Dai Er Ke Za Zhi. 2015 Sep;17(9):980-3. Chinese. PMID: 26412183. METASTUDY

  22. Scassellati, Bonvicini, Benussi, Ghidoni, Squitti (2020): Neurodevelopmental disorders: Metallomics studies for the identification of potential biomarkers associated to diagnosis and treatment. J Trace Elem Med Biol. 2020 Jul;60:126499. doi: 10.1016/j.jtemb.2020.126499. Epub 2020 Mar 16. PMID: 32203724. METASTUDIE

  23. Noorazar, Malek, Aghaei, Yasamineh, Kalejahi (2020): The efficacy of zinc augmentation in children with attention deficit hyperactivity disorder under treatment with methylphenidate: A randomized controlled trial. Asian J Psychiatr. 2020 Feb;48:101868. doi: 10.1016/j.ajp.2019.101868. PMID: 31841818. n = 60

  24. Granero, Pardo-Garrido, Carpio-Toro, Ramírez-Coronel, Martínez-Suárez, Reivan-Ortiz (2021): The Role of Iron and Zinc in the Treatment of ADHD among Children and Adolescents: A Systematic Review of Randomized Clinical Trials. Nutrients. 2021 Nov 13;13(11):4059. doi: 10.3390/nu13114059. PMID: 34836314; PMCID: PMC8618748. METASTUDIE

  25. Effatpanah, Rezaei, Effatpanah, Effatpanah, Varkaneh, Mousavi, Fatahi, Rinaldi, Hashemi (2019): Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysis. Psychiatry Res. 2019 Feb 19;274:228-234. doi: 10.1016/j.psychres.2019.02.043.

  26. Hinghofer-Szalkay (physiologie.cc Abruf 2019): Humoral-neuronale Steuerung und Kontrolle von Organsystemen: Applikation, Transport, Metabolismus und Clearance

  27. Butler (2019): Magnesium Supplement and the 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: A Potential Treatment? Int J Mol Sci. 2019 Jun 14;20(12). pii: E2914. doi: 10.3390/ijms20122914.

  28. Hemamy, Heidari-Beni, Askari, Karahmadi, Maracy (2020): Effect of Vitamin D and Magnesium Supplementation on Behavior Problems in Children with Attention-Deficit Hyperactivity Disorder. Int J Prev Med. 2020 Jan 24;11:4. doi: 10.4103/ijpvm.IJPVM_546_17. PMID: 32089804; PMCID: PMC7011463.

  29. Hemamy, Pahlavani, Amanollahi, Islam, McVicar, Askari, Malekahmadi (2021): The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial. BMC Pediatr. 2021 Apr 17;21(1):178. doi: 10.1186/s12887-021-02631-1. PMID: 33865361; PMCID: PMC8052751. n = 66

  30. Tan, Wei, Zhang, Lu, Li (2011): [Relationship between serum ferritin levels and susceptibility to attention deficit hyperactivity disorder in children: a Meta analysis]. Zhongguo Dang Dai Er Ke Za Zhi. 2011 Sep;13(9):722-4. Chinese. PMID: 21924020. 5 Studien, n = 258 METASTUDIE

  31. McWilliams, Singh, Leung, Stockler, Ipsiroglu (2022): Iron deficiency and common neurodevelopmental disorders-A scoping review. PLoS One. 2022 Sep 29;17(9):e0273819. doi: 10.1371/journal.pone.0273819. PMID: 36173945. METASTUDIE

  32. Wang, Huang, Zhang, Qu, Mu (2017): Iron Status in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis. PLoS One. 2017 Jan 3;12(1):e0169145. doi: 10.1371/journal.pone.0169145. PMID: 28046016; PMCID: PMC5207676. METASTUDIE

  33. Tseng, Cheng, Yen, Chen, Stubbs, Whiteley, Carvalho, Li, Chen, Yang, Tang, Chu, Yang, Liang, Wu, Lin (2018): Peripheral iron levels in children with attention-deficit hyperactivity disorder: a systematic review and meta-analysis. Sci Rep. 2018 Jan 15;8(1):788. doi: 10.1038/s41598-017-19096-x. PMID: 29335588; PMCID: PMC5768671. 17 Studien mit n = 6.251 METASTUDIE

  34. Wang, Yu, Fu, Yeh, Hsu, Yang, Yang, Huang, Wei, Chen, Chiang, Pan (2019): Dietary Profiles, Nutritional Biochemistry Status, and Attention-Deficit/Hyperactivity Disorder: Path Analysis for a Case-Control Study. J Clin Med. 2019 May 18;8(5). pii: E709. doi: 10.3390/jcm8050709. n = 432

  35. Magula, Moxley, Lachman (2019): Iron deficiency in South African children and adolescents with attention deficit hyperactivity disorder. J Child Adolesc Ment Health. 2019 Jul 24:1-8. doi: 10.2989/17280583.2019.1637345.

  36. Donfrancesco R, Parisi P, Vanacore N, Martines F, Sargentini V, Cortese S (2013): Iron and ADHD: time to move beyond serum ferritin levels. J Atten Disord. 2013 May;17(4):347-57. doi: 10.1177/1087054711430712. PMID: 22290693.

  37. Schulze M, Coghill D, Lux S, Philipsen A, Silk T (2024): Assessing brain iron and its relationship to cognition and comorbidity in children with ADHD with quantitative susceptibility mapping (QSM). Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Aug 30:S2451-9022(24)00250-7. doi: 10.1016/j.bpsc.2024.08.015. PMID: 39218036.

  38. Adisetiyo, Gray, Jensen, Helpern (2019): Brain iron levels in attention-deficit/hyperactivity disorder normalize as a function of psychostimulant treatment duration. Neuroimage Clin. 2019 Aug 26;24:101993. doi: 10.1016/j.nicl.2019.101993.

  39. Shvarzman R, Crocetti D, Rosch KS, Li X, Mostofsky SH (2022): Reduced basal ganglia tissue-iron concentration in school-age children with attention-deficit/hyperactivity disorder is localized to limbic circuitry. Exp Brain Res. 2022 Oct 27. doi: 10.1007/s00221-022-06484-7. Epub ahead of print. PMID: 36301336.

  40. Moos (2002): Brain iron homeostasis. Dan Med Bull. 2002 Nov;49(4):279-301.

  41. Moreno-Fernández, López-Aliaga, García-Burgos, Alférez, Díaz-Castro (2019): Fermented Goat Milk Consumption Enhances Brain Molecular Functions during Iron Deficiency Anemia Recovery. Nutrients. 2019 Oct 7;11(10):2394. doi: 10.3390/nu11102394. PMID: 31591353; PMCID: PMC6835798.

  42. Leung, Singh, McWilliams, Stockler, Ipsiroglu (2020): Iron deficiency and sleep – A scoping review. Sleep Med Rev. 2020 Jun;51:101274. doi: 10.1016/j.smrv.2020.101274. PMID: 32224451. REVIEW

  43. Quiroz, Gulyani, Ruiqian, Bonaventura, Cutler, Pearson, Allen, Earley, Mattson, Ferré (2016): Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome. Neuropharmacology. 2016 Dec;111:160-168. doi: 10.1016/j.neuropharm.2016.09.002. PMID: 27600688; PMCID: PMC5056844.

  44. Metzgeroth, zitiert in Himmer (2022): Bleiern müde, Süddeutsche Zeitung 4./5./6. Juni 2022, Seite 33

  45. Bieger (2011): Neurostress Guide, Seite 26

  46. Bieger (2006): Neuroscience Guide – Ein innovatives, diagnostisches und therapeutisches Stufenprogramm bei Neurotransmitter-Störungen, Seite 19

  47. Shih JH, Zeng BY, Lin PY, Chen TY, Chen YW, Wu CK, Tseng PT, Wu MK. Association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis. Neuropsychiatr Dis Treat. 2018 Jul 18;14:1831-1842. doi: 10.2147/NDT.S165378. PMID: 30140155; PMCID: PMC6054766. 4 Studien, n = 1.174 METASTUDIE

  48. Shih, Zeng, Lin, Chen, Chen, Wu, Tseng, Wu (2018): Association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis. Neuropsychiatr Dis Treat. 2018 Jul 18;14:1831-1842. doi: 10.2147/NDT.S165378. PMID: 30140155; PMCID: PMC6054766. 4 Studien, n = 1.174 METASTUDIE

  49. Broberg, Taj, Guazzetti, Peli, Cagna, Pineda, Placidi, Wright, Smith, Lucchini, Wahlberg (2019): Manganese transporter genetics and sex modify the association between environmental manganese exposure and neurobehavioral outcomes in children. Environ Int. 2019 Sep;130:104908. doi: 10.1016/j.envint.2019.104908. n = 645

  50. Scassellati, Bonvicini, Faraone, Gennarelli (2012): Biomarkers and Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analyses. Journal of the American Academy of Child & Adolescent Psychiatry, Volume 51, Issue 10, 1003 – 1019.e20 REVIEW

  51. Scassellati, Bonvicini, Faraone, Gennarelli (2012): Biomarkers and Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analyses. Journal of the American Academy of Child & Adolescent Psychiatry, Volume 51, Issue 10, 1003 – 1019.e20

  52. Llanos, Mercer (2004): The Molecular Basis of Copper Homeostasis Copper-Related Disorders. DNA and Cell BiologyVol. 21, No. 4. https://doi.org/10.1089/104454902753759681

  53. Yu, Jiang, Wang, Xie (2008): Copper (Cu2+) induces degeneration of dopaminergic neurons in the nigrostriatal system of rats. Neuroscience Bulletin. April 2008, Volume 24, Issue 2, pp 73–78

  54. Sakhr, Hassan, Desoky (2020): Possible Associations of Disturbed Neurometals and Ammonia with Glycaemic Control in Type 1 Diabetic Children with Attention Deficit Hyperactivity Disorder. Biol Trace Elem Res. 2020 Feb 5:10.1007/s12011-020-02063-5. doi: 10.1007/s12011-020-02063-5. PMID: 32020524. n = 60

  55. Kozielec, Starobrat-Hermelin, Kotkowiak (1994): Wystepowanie niedoborów wybranych biopierwiastków u dzieci z nadpobudliwościa [Deficiency of certain trace elements in children with hyperactivity]. Psychiatr Pol. 1994 May-Jun;28(3):345-53. Polish. PMID: 8078966. n = 50

  56. Yorbik, Mutlu, Özdağ, Olgun, Eryilmaz, Ayta (2016): Possible Effects of Copper and Ceruloplasmin Levels on Auditory Event Potentials in Boys with Attention Deficit Hyperactivity Disorder. Noro Psikiyatr Ars. 2016 Dec;53(4):321-327. doi: 10.5152/npa.2016.12659. PMID: 28360806; PMCID: PMC5353038. n = 65

  57. Sui X, Liu T, Zou Z, Zhang B (2023): Appraising the role of circulating concentrations of micronutrients in attention deficit hyperactivity disorder: a Mendelian randomization study. Sci Rep. 2023 Dec 9;13(1):21850. doi: 10.1038/s41598-023-49283-y. PMID: 38071357; PMCID: PMC10710398.

  58. Perham, Shaikh, Lee, Darling, Rucklidge (2020): Toward ‘element balance’ in ADHD: an exploratory case control study employing hair analysis. Nutr Neurosci. 2020 Jan 3:1-11. doi: 10.1080/1028415X.2019.1707395. n = 107

  59. Surman, Vaudreuil, Boland, Rhodewalt, DiSalvo, Biederman (2020): L-Threonic Acid Magnesium Salt Supplementation in ADHD: An Open-Label Pilot Study. J Diet Suppl. 2020 Mar 12:1-13. doi: 10.1080/19390211.2020.1731044. PMID: 32162987. n = 15

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