Amitriptyline for ADHD

Amitriptyline is a tricyclic antidepressant

• Serotonergic, as a serotonin reuptake inhibitor, whereby this effect predominates¹
• Weaker also noradrenergic

The metabolite of amitryptiline is nortriptyline, which inhibits the reuptake of noradrenaline. For more information, see ⇒ Nortriptyline in AD(H)S.

Amitryptiline has a sleep-promoting and anxiolytic effect. Like trimipramine, it does not impair REM sleep.