Dopamine
Dopamine (3,4-dihydroxytyramine) is the neurotransmitter with the greatest involvement in ADHD.1
Dopamine is a monoamine, like noradrenaline and adrenaline, whose precursor is dopamine. At 80 %, dopamine is the most common monoamine in the brain.
in 1910, it was still assumed that dopamine was only an inactive intermediate in the synthesis of catecholamines to noradrenaline and adrenaline.2 It was not until 1957 that the neurotransmitter function of dopamine was discovered.3 Carlsson was awarded the Nobel Prize for this discovery in 20004
ADHD symptoms are primarily mediated by disorders of the dopaminergic system.
1. Control ranges through dopamine
2. The 5 dopaminergic systems of the brain
3. Interactions of the dopaminergic brain areas
4. Dopamine formation and storage
5. Dopamine release
6. Tonic / phasic / extracellular dopamine
7. Dopamine effect on receptors
8. Dopamine reuptake, dopamine degradation
9. Regulation of dopamine
10. ADHD - Disorders of the dopamine system
11. Dopamine and stress
12. Autism as a dopaminergic Disorder
13. Depression as a dopaminergic Disorder
14. Parkinson’s - another Disorder of the Dopamine System
15. Measurement of dopamine
Franck (2003): Hyperaktivität und Schizophrenie – eine explorative Studie; Dissertation, Seite 66, mit weiteren Nachweisen ↥
Barger G, Dale HH (1910): Chemical structure and sympathomimetic action of amines. J Physiol. 1910 Oct 11;41(1-2):19-59. doi: 10.1113/jphysiol.1910.sp001392. PMID: 16993040; PMCID: PMC1513032. ↥
CARLSSON A, LINDQVIST M, MAGNUSSON T, WALDECK B (1958): On the presence of 3-hydroxytyramine in brain. Science. 1958 Feb 28;127(3296):471. doi: 10.1126/science.127.3296.471. PMID: 13529006. ↥
Petersson M, Uvnäs-Moberg K (2024): Interactions of Oxytocin and Dopamine-Effects on Behavior in Health and Disease. Biomedicines. 2024 Oct 24;12(11):2440. doi: 10.3390/biomedicines12112440. PMID: 39595007; PMCID: PMC11591571. REVIEW ↥